+49-6221-8936-157
contact [at] therapyselect [dot] deFind Effective Drugs before Starting the Therapy!
No two cancer therapies are the same!
There is a wide range of different drugs which can be applied in treatment of ovarian cancer. This treatment includes classical chemotherapeutic substances, yet also anti-hormonal drugs and new targeted drugs are used. Which medication should be prescribed depends on different factors, e.g. the cancer stage and the general condition of the patient. In order to choose the right therapy there are medical guidelines for physicians. However, in some situations the guidelines do not give clear recommendations and propose equivalent treatment options.
Diagnostic assays can help to identify effective and ineffective drugs before the start of a therapy. The available spectrum of therapeutics can thereby be limited on the most promising substances. Our diagnostics contribute avoidance of unnecessary side effects as a consequence of an ineffective therapy and save valuable treatment time. Therefore we offer the following diagnostic tests:
CTR-Test® - An efficacy test working on living tumor cells
PCDx™ - A tumor-biomarker-analysis working on non-living, conserved tumor cells
Guardant360® - A tumor-biomarker-analysis working with blood
Guidelines for the Treatment of Ovarian Cancer
Hereafter you can find an overview about guideline-recommendations, which are elaborated by medical specialist associations:
Drug therapy regimes differ for primary and recurrent ovarian cancer. While there are different options for primary treatment depending on the stage of cancer, platinum-based chemotherapy is generally recommended. If a patient suffers a relapse, the choice for an appropriate treatment is based on the time span between discontinuation of chemotherapy and the occurrence of the relapse. Tumors relapsing within 6 months are called platinum-resistant, those relapsing after 6 months are referred to as platinium-sensitive.
| first-line therapy | early ovarian cancer | chemotherapy containing cisplatin (therapy should contain carboplatin) |
| advanced ovarian cancer | carboplatin + paclitaxel (+ bevacizumab) | |
| recurrence | platinum-sensitive tumor | carboplatin + gemcitabine + bevacizumab |
| carboplatin + doxorubicin (liposomal) | ||
| carboplatin + paclitaxel | ||
| carboplatin + gemcitabine | ||
| platinum-resistant tumor | doxorubicin (liposomal) | |
| topotecan | ||
| gemcitabine | ||
| paclitaxel |
This table is based on the "S3-Leitlinie Diagnostik, Therapie und Nachsorge maligner Ovarialtumoren", issued by the Association of the Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V., AWMF), the German Cancer Society (Deutsche Krebsgesellschaft, DKG) and the Germany Society for Gynaecology and Obstetrics (Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, DGGG). [1]
Efficacy Tests of Drugs for Ovarian Cancer
Which drugs can be tested in their efficacy by our diagnostic tests? The following tables give you information on the substances recommended by the guidelines, but also about further drugs which can be found as additional treatment options in literature. These substances are classified in the following categories:
Anti-Hormonal Drugs (subgroup of targeted drugs)
In addition the frequently used combination therapies are listed below.
The testabilities for the CTR-Test® and the PCDx™ are also given.
Chemotherapeutics
| substance name | efficacy testable by
| efficacy testable by
| efficacy testable by
| Referenz |
|---|---|---|---|---|
| altretamine | no validation yet | no biomarkers yet | not yet | [3] |
| bleomycin | yes | no biomarkers yet | not yet | [2] |
| capecitabine | yes | yes | not yet | [3] |
| carboplatin | yes | yes | yes | [1], [2] |
| cisplatin | yes | yes | yes | [2] |
| cyclophosphamide | yes | no biomarkers yet | not yet | [2] |
| docetaxel | yes | yes | not yet | [3] |
| doxorubicin | yes | yes | not yet | [3] |
| doxorubicin (liposomal) | yes | yes | not yet | [1], [2] |
| etoposide | yes | no biomarkers yet | not yet | [2] |
| gemcitabine | yes | yes | not yet | [1], [2] |
| irinotecan | yes | yes | not yet | [3] |
| melphalan | yes | no biomarkers yet | not yet | [3] |
| oxaliplatin | yes | yes | yes | [3] |
| paclitaxel | yes | yes | not yet | [1], [2] |
| pemetrexed | no | yes | not yet | [3] |
| topotecan | yes | yes | not yet | [1], [2] |
| trabectedin | yes | not yet | not yet | [1] |
| treosulfan | yes | no biomarkers yet | not yet | [1] |
| vinorelbine | yes | not yet | not yet | [3] |
Targeted Drugs
| substance name | efficacy testable by
| efficacy testable by
| efficacy testable by
| Referenz |
|---|---|---|---|---|
| bevacizumab | no | yes | not yet | [1] |
| olaparib | no validation yet | yes | yes | [3] |
Anti-Hormonal Drugs
| substance name | efficacy testable by
| efficacy testable by
| efficacy testable by
| Referenz |
|---|---|---|---|---|
| anastrozole | not possible | yes | yes | [3] |
| exemestane | not possible | yes | yes | [3] |
| letrozole | not possible | yes | yes | [3] |
| leuprorelin | not possible | not yet | not yet | [3] |
| megestrol | no validation yet | yes | not yet | [3] |
| tamoxifen | yes | yes | yes | [3] |
Frequently Used Combination Therapies
| substance name | reference |
|---|---|
| bleomycin + cisplatin + etoposide phosphate (combination name: PEB) | [2] |
| bevacizumab + carboplatin + gemcitabine | [1] |
| carboplatin + cyclophosphamide | [2] |
| carboplatin + gemcitabine | [1], [2] |
| carboplatin + paclitaxel | [1], [2] |
| carboplatin + doxorubicin (liposomal) | [1], [2] |
The drugs listed here were identified as potential therapy options after an accurate literature research. Completeness cannot be guaranteed. Status: September 2016.
